Continuous: Mann–Whitney U. Categorical: Fisher's exact. Computed in DuckDB v1.1 against OMOP CDM v5.4 · Source: St. Mercy General Hospital EHR
Table 1. Baseline Characteristics by Depression Status
| Characteristic |
Total (N=8) | Depression (n=4) |
No Depression (n=4) | P-value |
| Age at CRC diagnosis, mean ± SD, years | 57.2 ± 8.1 | 53.2 ± 7.3 | 61.2 ± 5.2 | 0.306 |
| Sex, male, n (%) | 4 (50.0) | 1 (25.0) | 3 (75.0) | 0.486 |
| Psychiatric comorbidities |
| Major depressive disorder, n (%) | 4 (50.0) | 4 (100.0) | 0 (0.0) | 0.029 |
| Anxiety disorder, n (%) | 4 (50.0) | 1 (25.0) | 3 (75.0) | 0.486 |
| Follow-up |
| Follow-up duration, mean ± SD, years | 4.9 ± 1.1 | 4.7 ± 0.8 | 5.0 ± 1.4 | 0.886 |
| Person-years of observation | 38.9 | 18.9 | 20.0 | — |
| All-cause mortality, n (%) | 3 (37.5) | 1 (25.0) | 2 (50.0) | 1.000 |
CRC = colorectal cancer; SD = standard deviation. P-values: Mann–Whitney U (continuous); Fisher's exact (categorical).
Crude HR = incidence rate ratio. Adjusted: Mantel–Haenszel by age strata and sex. n=8; exploratory estimates.
Table 2. Depression and All-Cause Mortality in CRC Patients
A. Mortality outcomes
| Depression (n=4) | No Depression (n=4) |
|---|
| Deaths, n (%) | 1 (25.0) | 2 (50.0) |
| Person-years | 18.9 | 20.0 |
| Incidence rate (per person-year) | 0.053 | 0.100 |
B. Crude and adjusted hazard ratios
| Model | HR | 95% CI | P-value |
|---|
| Crude | 0.53 | 0.05–5.84 | 1.000 |
| Age-adjusted | 0.51 | 0.04–6.12 | 0.587 |
| Age- and sex-adjusted† | 0.48 | 0.05–4.61 | 0.524 |
C. Covariates in fully adjusted model
| Variable | HR | 95% CI | P-value |
|---|
| Depression (yes vs. no) | 0.48 | 0.05–4.61 | 0.524 |
| Age at diagnosis (per 1-year increase) | 1.09 | 0.92–1.29 | 0.318 |
| Sex (male vs. female) | 1.34 | 0.14–12.8 | 0.797 |
HR = hazard ratio; CI = confidence interval. †n=8; all estimates exploratory. P-values: Fisher's exact (crude); Wald test (adjusted).